The Link between Cerebrovascular Hemodynamics and Rehabilitation Outcomes after Aneurysmal Subarachnoid Hemorrhage

AbstractObjectiveTo assess the relation between cerebrovascular function early after aneurysmal subarachnoid hemorrhage (SAH) onset and functional and rehabilitation outcomes.DesignObservational cohort study of SAH patients (n=133) admitted to rehabilitation (n=49), discharged home (n=52), or died before discharge (n=10). Hemodynamic markers of cerebral autoregulatory function obtained from blood flow velocities in the middle cerebral artery and arterial pressure waveforms, recorded daily on days 2–4 after symptom onset, and functional independence measure (FIM™) scores and FIM efficiency for those admitted to acute rehabilitation.ResultsCompared to those discharged home, the range of pressures within which autoregulation is effective was lower in patients admitted to rehabilitation (4.6+0.2 vs 3.9+0.2 mmHg) and those who died (2.7+0.4; p=0.04). For those admitted to rehabilitation, autoregulatory range and the ability of cerebrovasculature to increase flow were related to discharge FIM score (R2=0.33 and 0.43; p

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/2CSrQKX
via IFTTT