Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation [Immunology and Inflammation]

Despite decades of research, mechanisms controlling T cell activation remain only partially understood, which hampers T cell-based immune cancer therapies. Here, we performed a genome-wide CRISPR screen to search for genes that regulate T cell activation. Our screen confirmed many of the known regulators in proximal T cell receptor signaling...

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