Reply to Chien: Clarification of the effect of ligand on {gamma}{delta}-TCR repertoire selection [Biological Sciences]

In our recent publication (1), we report that the EGYEL motif, previously found to promote T22-reactivity, was depleted from the mature CD24low pool of γδ-T cells that developed in H-2T–deficient mice, indicating that ligand was influencing the γδ-T cell receptor (TCR) repertoire (1). In her letter, Chien (2) suggests that...

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