Identification and Characterization of Salmonella enterica Serotype Newport Isolates with Decreased Susceptibility to Ciprofloxacin in the United States [PublishAheadOfPrint]

Nontyphoidal Salmonella (NTS) causes an estimated 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths each year in the United States. Decreased susceptibility to ciprofloxacin (DSC) has historically been associated with chromosomal mutations (QRDR), but plasmid-mediated quinolone resistance (PMQR) genes are increasing. To investigate DSC among serotype Newport, we examined 40 isolates with DSC from 1996-2016. Thirty isolates (71%) contained the PMQR gene, qnrB, and eight isolates (19%) contained a QRDR....

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