Decreased interleukin-35 serum levels in patients with chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU), a mast cell-driven disease, is defined as the spontaneous appearance of wheals, angioedema or both for > 6 weeks for unknown or known causes.1 Mast cells, as one of the major effector cells in the immune response system, play important roles in the pathogenesis of CSU. Interleukin (IL)-35 is a new anti-inflammatory cytokine which belongs to the IL-12 family and is composed of two subunits: Epstein-Barr virus-induced gene 3 (EBI3) and IL-12p35. IL-35 is widely recognized as a definite immune suppressor with a huge potent of suppression.

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