Eosinophil degranulation products drive a pro-inflammatory fibroblast phenotype

Publication date: Available online 21 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Ksenija Bernau, Jonathan P. Leet, Stephane Esnault, Andrea L. Noll, Michael D. Evans, Nizar N. Jarjour, Nathan Sandbo

Teaser

In this study, we found that eosinophil-derived degranulation products stimulate bronchial fibroblasts to release chemotactic factors that promote neutrophil migration. This finding suggests that eosinophil-fibroblast interactions may promote airway neutrophilia in severe asthma.


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