G-quadruplex DNA targeting alters class switch recombination in B cells and attenuates allergic inflammation

Publication date: Available online 20 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Zeinab Dalloul, Pauline Chenuet, Iman Dalloul, François Boyer, Jean-Claude Aldigier, Brice Laffleur, Yolla El Makhour, Bernhard Ryffel, Valerie FJ. Quesniaux, Dieudonnée Togbé, Jean-Louis Mergny, Jeanne Cook-Moreau, Michel Cogné

Teaser

Targeting immunoglobulin switch regions with a G4-DNA binding drug offers a novel immunomodulatory strategy reducing class-switched antibody secretion.


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