GM-CSF Therapy in Human CARD9 Deficiency

Publication date: Available online 8 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Rebecca A. Drummond, Fatema Tuz Zahra, Mukil Natarajan, Muthulekha Swamydas, Amy P. Hsu, L. Joseph Wheat, Christina Gavino, Donald C. Vinh, Steven H. Holland, Constantinos M. Mikelis, Michail S. Lionakis

Teaser

CARD9 deficiency is associated with life-threatening fungal infections of the CNS. This work shows that the H-RAS/RASGRF1/ERK pathway is intact in the c.170G>A (p.R57H) CARD9 missense mutation, a finding that correlates with the clinical outcome of GM-CSF therapy.


https://ift.tt/2Mdksef