Potency of solithromycin against fast and slow growing chlamydial organisms [PublishAheadOfPrint]

Evidence is provided that solithromycin is a bactericidal against not only fast growing chlamydial organisms but also those slowed by IFN in vitro. At sub-lethal concentrations, Sol impedes homotypic fusion of Chlamydia-containing vacuoles and reduces secretion of the type III secretion (T3S) effector, IncA. Sol may therefore represent a potential new clinical treatment for Chlamydia infections. Selective perturbation of the T3S system suggests a novel mode of antibacterial action for Sol that warrants further investigation.

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