Validation of Heelstick Microsampling to Optimize Micafungin Doses in Neonates and Young Infants [PublishAheadOfPrint]

Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (IV) and heel-stick capillary (HSC) sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm, with systemic candidiasis. The mean (SD) micafungin AUC_inf was 316 (65.0) h·mg/L based on HSC concentrations that strongly correlated (R²= 0.92) with IV values to support dose adjustment.

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