Amikacin and gentamicin pharmacokinetic behaviors after nebulization were determined by comparing plasma and pulmonary epithelial lining fluid (ELF) concentrations in rats after intra-tracheal and intravenous administrations. ELF areas under concentrations time-curves were 874 and 162 times higher after nebulization than after IV administration for amikacin and gentamicin respectively. Even if both molecules appear as good candidates for nebulization, these results demonstrate a much higher targeting advantage of nebulization for amikacin than for gentamicin.
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