New diagnostic criteria for eosinophilic esophagitis

It has been quite a journey for the entity known as proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE). The new international consensus diagnostic criteria for eosinophilic esophagitis (EoE), recently published by Dellon et al1 and summarized by Spergel et al2 in this issue, currently state that the diagnosis of EoE can be made if esophageal symptoms and esophageal eosinophilia are present after ruling out other causes of esophageal eosinophilia. An 8- to 12-week trial with a high dose of PPI to rule out PPI-REE, as stated in the 2011 consensus recommendations,3 is no longer considered a requirement to confirm the diagnosis of EoE but rather a therapeutic option for EoE.

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