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Σάββατο 20 Οκτωβρίου 2018

Maturation of auditory brainstem response in early term infants at 6 weeks and 9 months

Publication date: Available online 19 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Mingyan Li, Li Zhu, Dan Yao, Lin Xu, Chai Ji

Abstract
Background

Emerging evidence indicates that infants who were born between 37∼38 weeks of gestation are at higher risk of adverse long-term neurodevelopmental outcomes. Yet little is known about the auditory neural maturation during the first year of their life.

Aim

To compare the development of auditory brainstem response in early term (ET, 37∼38 weeks gestational age, GA) and full term (FT, 39∼41 weeks GA) infants.

Methods

126 infants received ABR testing at 6 weeks. 107 of them returned for the second assessment at 9 months, among which, 93 completed the ABR recordings. Comparison of the ABR variables were made depending on gestational age.

Results

Analysis of covariance (ANCOVA) was used to identify the differences in ABR outcomes between two groups. After controlling for confounders, latencies for wave III, V and I-III, III-V and I-V intervals were prolonged in ET group compared with FT group at 6 weeks (all p<0.03). ABR parameters of both groups developed as the infants got older. At 9 months, ET infants remain showing the longer wave V latency and I-V interval (all p <0.02) than FT infants.

Conclusion

During early postnatal life, ET has a different pattern of functional auditory brainstem development comparing with FT infants. The prolonged auditory conduction time suggests less mature of the central auditory system in ET infants before 9 months.



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