Anti-aging effects of ingenol mebutate for patients with actinic keratosis

To the Editor: Ingenol mebutate (IM) gel has been approved by the Food and Drug Administration as a topical field-directed therapy for actinic keratosis (AK) and has been shown to cure subclinical and clinically apparent AKs.1 Recently, there have been reports of improvements in skin elasticity, wrinkles, and mottled pigmentation after the application of IM gel in patients with multiple AK lesions.2,3 In this study, we aimed to investigate histologic and molecular alterations after field cancerization by using topical IM gel in patients with multiple AK lesions and elucidate the mechanism underlying the skin-rejuvenating effect of IM gel.

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