Gamma‐delta T cell large granular lymphocyte leukemia with multiple cutaneous nodules that showed spontaneous regression

Abstract

T cell large granular lymphocyte leukemia (T‐LGLL) is a rare chronic lymphoproliferative disorder of mature post‐thymic large granular lymphocytes (LGL); either cytotoxic T‐lymphocytes or natural killer cells.¹ Major phenotype of LGL cells is TCRαβ+CD3+CD4‐CD5+CD8+CD27‐CD28‐CD45‐CD57+.² Less than 10% of cases express TCRγδ instead of TCRαβ.² Most cases of T‐LGLL have an indolent course¹ and its cutaneous manifestations have been poorly documented.

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