Identification of DNA methylation module in seasonal allergic rhinitis

Publication date: Available online 29 November 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Zhenfeng Gao, Mengmeng Huang, Zhe Qu, Junchao Wang, Xiaolan Cai

Abstract

Objective

In this study, we aimed to characterize the significant DNA methylation module of seasonal allergic rhinitis.

Methods

Methylation profiling E-GEOD-50222 was obtained from ArrayExpress database. Differential co-methylation network (DCN) was constructed based on the methylation data. From the DCN, we characterized multiple differential modules (M-DMs). Significant module was mapped to pathways to identify significant enriched pathways.

Results

At the criteria of absolute Pearson coefficient value > 0.8, the edges were chose to construct DCN. In the DCN, 16 seed genes were identified. Seed genes were used to construct M-DMs. After statistical analysis, one significant module with p<0.05 were obtained. After pathways enrichment analysis, 17 significant pathways with p<0.05 were obtained, and most of these pathways were associated with DNA replication.

Conclusion

One multiple differential module was identified in SAR, and seventeen significant pathways mapped by the module were identified as important factors in SAR. These results may provide new insights into the molecular mechanism of DNA methylation in SAR.

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