Nuclear expression of onco-suppressors NM23-H1 and maspin are associated with lower recurrence rate in laryngeal carcinoma

Publication date: Available online 22 November 2018

Source: American Journal of Otolaryngology

Author(s): Gino Marioni, Giancarlo Ottaviano, Cosimo de Filippis, Elena Fasanaro, Benedetto Randon, Stefano Meneghesso, Luciano Giacomelli, Laura Astolfi, Stella Blandamura

Abstract

Purpose

The main aim of the study was to preliminarily investigate the possibly related role of nuclear onco-suppressors maspin and nm23-H1, a metastasis suppressor, in laryngeal squamous cell carcinoma (LSCC).

Materials and methods

Maspin expression pattern and nuclear nm23-H1 expression were ascertained in 62 consecutive LSCCs.

Results

Recurrence rate was significantly lower in patients with a nuclear maspin pattern of expression; nuclear nm23-H1 expression was significantly lower in patients who experienced disease recurrence. Disease free survival (DFS) was significantly longer in patients with maspin nuclear pattern or with nuclear nm23-H1 expression ≥10%. A significant association was found between nuclear nm23-H1 expression and maspin pattern of expression in LSCC. KNN discriminant analysis considered N status, maspin sub-cellular localization and nuclear nm32-H1 expression. The selected variables' accuracy in terms of relapse was 82%. Positive predictive accuracy was 100%, and negative predictive accuracy 79%.

Conclusions

Nuclear nm23-H1 expression and maspin pattern, also in association, show promise as recurrence indicators in LSCC. Further studies are needed to shed more light on the nm23-H1 mechanism of action in LSCC and thus find ways to restore nm23-H1 loss. These preliminary findings suggest that re-activating maspin functions might represent an important goal in the treatment of advanced LSCC.

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