We Need to Talk About Notch:Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Disease

Abstract

The Notch signaling pathway is a highly evolutionarily conserved signaling pathway comprised of four type 1 transmembrane receptors. Canonical Notch signaling is stimulated by Jagged and Delta ligands resulting in translocation of the Notch Intracellular domain (ICD) to the nucleus resulting in activation of transcription factor CSL. Increased Notch activity is associated with epidermal keratinocyte maturation, proliferation and innate immune activation through maturation of dendritic cells, T cells and macrophages.

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