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Σάββατο 22 Δεκεμβρίου 2018

Blood eosinophils may predict radiographic sinus opacification in patients with chronic rhinitis

Background

The association between chronic rhinosinusitis (CRS) and chronic rhinitis remains unclear. The aim of this study was to estimate the predictive factors for sinus opacification in chronic rhinitis patients without obvious CRS.

Methods

We retrospectively studied a total of 332 adult patients with chronic rhinitis who visited our clinic from January 2015 to December 2017. All of the patients underwent endoscopic examination, allergy test, and osteomeatal‐unit computed tomography. The subjects were assigned to the normal sinus (NS) group (Lund‐Mackay score [LMS] <5) and sinus opacification (SO) group (LMS ≥5).

Results

A total of 288 patients were eligible for this study. Of them, 183 (63.5%) were classified in the NS group and 105 (36.5%) in the SO group. Total immunoglobulin E (IgE) level and peripheral blood eosinophil count were significantly higher in the SO than NS group (p = 0.031 and p < 0.0001, respectively). Using Pearson correlation coefficients, we determined that eosinophil count had a positive correlation with the LMS (r = 0.282). In logistic analysis, the interquartile range increase (0.19 × 109/L) of the eosinophil count was significantly associated with SO (odds ratio [OR] 1.76; 95% confidence interval [CI], 1.30 to 2.39). After adjusting for age, gender, smoking, drinking, and underlying disease, the interquartile range increase of the eosinophil count increased the odds of SO to 1.69‐fold; this increase was statistically significant (p = 0.007; 95% CI, 1.17 to 2.43).

Conclusion

Peripheral blood eosinophil count is an independent predictor of CRS in patients with chronic rhinitis.



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