Emergence of OXA-232 carbapenemase-producing Klebsiella pneumoniae that carries a pLVPK-like virulence plasmid among elderly patients in China [Mechanisms of Resistance]

This study reported the clonal dissemination of OXA-232-producing ST15 carbapenem-resistant K. pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and hospitalized for a prolonged period; yet they slowly recovered upon antimicrobial therapy. The bla_OXA-232 gene was in a 6.1 Kb ColKP3-type non-conjugative plasmid. The strains displayed multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control the further transmission.

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