“Invasive Proliferative Gelatinous Mass” of Hidradenitis Suppurativa contains distinct inflammatory components

Abstract

As defined by the European Dermatology Forum, Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle in the axillae, inguinal and anogenital regions (Fig 1a, top). For severe cases, surgical management of lesions by "deroofing" is helpful. As first described by William Danby, sinus tracts contain an "invasive proliferative gelatinous mass (IPGM)" attached to the sinus tract epithelium[1]. However, the components of IPGM have not been investigated. We used existing, de‐identified, un‐matched samples of IPGM, serum and skin biopsies from normal subjects, HS patients, and acne patients to compare the composition of immune cells and cytokines all in an effort to understand the magnitude and potential biological impact of IPGM within HS lesions.

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