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Τρίτη 18 Δεκεμβρίου 2018

Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories [Microbiology]

The rotavirus (RV) genome is replicated and packaged into virus progeny in cytoplasmic inclusions called viroplasms, which require interactions between RV nonstructural proteins NSP2 and NSP5. How viroplasms form remains unknown. We previously found two forms of NSP2 in RV-infected cells: a cytoplasmically dispersed dNSP2, which interacts with hypophosphorylated NSP5;...

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