Αρχειοθήκη ιστολογίου

Παρασκευή 21 Δεκεμβρίου 2018

Prevalence and clinical implications of low-risk human papillomavirus among patients with recurrent respiratory papillomatosis in Rio de Janeiro, Brazil

Publication date: Available online 21 December 2018

Source: Auris Nasus Larynx

Author(s): Marcelo Cardoso Figueiredo, Mariana Chantre Justino, Lucas Delmonico, Rafaele Tavares Silvestre, Thiago Luz de Castro, Aline dos Santos Moreira, Jacyara Maria Brito Macedo, Maria da Glória da Costa Carvalho, Luciano Scherrer, Daniel José Matos de Medeiros Lima, Gilda Alves, Maria Helena Ornellas

Abstract
Objective

The aim of this study was to investigate the presence of human papillomavirus (HPV) in biopsy specimens from juvenile and adult patients with histopathological diagnosis of recurrent respiratory papillomatosis (RRP) treated in two public hospitals in Rio de Janeiro, Brazil.

Methods

We performed the detection and genotyping of HPV by PCR technique for the types 6, 11, 16, and 18 in biopsy specimens from 41 RRP patients.

Results

The juvenile onset RRP (JoRRP) corresponded to 61% and the adult onset RRP (AoRRP) corresponded to 39% of the study group. Prevalence of males was observed in both the adult (81.3%) and the juvenile (56%) groups. Lesions in the larynx were more frequent in the glottis (46%). Genotyping analysis only revealed patients with HPV-6 (34.1%), HPV-11(17.1%), and co-infection HPV-6 and -11 (48.8%). RRP severity was significantly associated with the JoRRP (p < 0.001), with extralaryngeal disease and more surgeries. However, no significant association between RRP severity and HPV types was found. One co-infected patient in the JoRRP died due to the evolution of the disease with lung involvement.

Conclusion

These results show the strong association of HPV-6 and/or HPV-11 types with RRP and could complement the diagnosis, prognosis, and therapies for these patients. In addition, the HPV vaccination should be encouraged to prevent the disease.



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