Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy

A stability difference-selective bond breakage strategy for the fabrication of large pore-sized hollow mesoporous ­organosilica nanoparticles (HMONs) is successfully developed. Moreover, surface-functionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drugs doxorubicin to reverse the multidrug resistance of ­cancer cells.

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1PLN0XV
via IFTTT