Decreased 5‐hydroxymethylcytosine immunoreactivity in primary Merkel cell carcinomas is a strong predictor for disease‐specific death

Abstract

Merkel cell carcinoma (MCC) is an infrequent malignant skin tumour with epithelial and neuroendocrine differentiation. Though it is a highly aggressive malignancy, the distinct molecular pathogenesis of MCC is not yet fully understood. Apart from DNA methylation, histone modification, and microRNA‐mediated and long non‐coding RNA‐mediated regulation, hydroxymethylation may also play an important role in cancer development. Loss of 5‐hydoxymethylcytosine (5‐hmc) has been reported in a variety of cancers, including skin malignancies such as melanoma.

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