PTX3 and D‐dimer in children with asthma: a real‐world study‐Reply

Abstract

Licari and colleagues detected plasma pentraxin 3 (PTX3) and serum D‐dimer levels, and reported significant elevated concentrations for both biomarkers in asthmatic patients compared with healthy controls, but neither was observed to be associated with clinical parameters.

Elevated PTX3 expressions in asthmatic airways were firstly observed by Zhang et al,¹ and the same group reported that PTX3 deletion enhanced airway inflammation, mucus production, and airway hyperresponsiveness in an ovalbumin‐induced asthma model through a TH17‐dominant phenotype.²

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