Latinos represent less than 1% of samples analyzed to date in genome‐wide association studies of cancer. The clinical value of genetic information in guiding personalized medicine in populations of non‐European ancestry will require additional discovery and risk locus characterization efforts across populations. In the present study, we performed a GWAS of PrCa in 2,820 Latino PrCa cases and 5,293 controls to search for novel PrCa risk loci and to examine the generalizability of known PrCa risk loci...
Objectives: The contribution of tumor subtypes (TS) in each stage of breast cancer with the use of contemporary therapies is unclear. The aim of this study was to analyze differences in overall survival (OS) by TS according to stage compared with other factors. Materials and Methods: We evaluated women with breast cancer diagnosed between 2010 and 2013 with known estrogen receptor and progesterone receptor (together hormone receptor [HR]) status and human epidermal growth factor receptor...
Objectives: Lymphovascular space invasion (LVSI) is a known prognostic factor for endometrial carcinomas. However, LVSI as a determinant of treatment benefit has not been fully elucidated. Methods and Materials: Data from the National Cancer Database for endometrial cancer from 2004 to 2012 was obtained. Univariate and multivariate analysis was performed to assess the impact of LVSI on overall survival (OS). Survival analysis was performed utilizing log-rank and Kaplan-Meier analyses. The...
Objectives: To utilize the RSSearch Patient Registry (RSSPR) to examine local control (LC), overall survival (OS), and toxicities following stereotactic body radiation therapy (SBRT) for stage I (T1-T2/N0) medically inoperable small cell lung carcinoma (SCLC). Materials and Methods: We searched the RSSPR for medically inoperable stage I SCLC patients treated with definitive SBRT. Potential predictive factors of OS were estimated using the Kaplan-Meier method as well as a Cox proportional...
Objectives: Little is known about how quality of life (QOL) can assist clinical decision-making for patients with hepatocellular carcinoma (HCC). This study aimed to investigate the reliability and validity of QOL as well as its prognostic value and utility. Materials and Methods: A prospective cohort of 300 HCC patients at various stages was recruited from 2015 to 2017 in Korea. The subjects answered the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire...
Background: The incidence of gastric cardia cancer (GCC) patients has been increasing, while the survival trends of GCC patients over time remains unclear. Thus, the aim of our study was to determine the survival trends of GCC patients over time using a population-based data in the United States. Methods: A total of 9044 surgically resected GCC patients during 1988 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were identified. The survival probabilities were...
Objectives: Most localized hepatocellular carcinoma (HCC) patients are not surgically operable or transplantation candidates, increasing the role for nonsurgical therapies. Ablative external beam radiotherapy (XRT) and transarterial radioembolization (TARE) are emerging radiotherapeutic treatments for localized HCC. We sought to evaluate their utilization and efficacy in a large nationwide cohort. Materials and Methods: We conducted an observational study of 2685 patients from the National...
Objectives: Thirty-day (30-day) mortality, a common posttreatment quality metric, is yet to be described following surgery for head and neck squamous cell carcinoma (HNSCC). This study aimed to measure 30-day postoperative mortality in HNSCC and describe clinical/nonclinical factors associated with 30-day mortality. Methods: In this retrospective cohort study, the National Cancer Database (2004 to 2013) was queried for eligible cases of HNSCC (n=91,858). Adult patients were included who were...
Background: Randomized control trials and population-based studies do not demonstrate a definitive benefit for adjuvant chemotherapy (ACT) in stage II colon cancer (CC). Tumor sidedness and microsatellite instability (MSI) status may predict response to ACT, but previous studies have limited microsatellite data. We assessed the efficacy of ACT and possible interaction with MSI status and tumor sidedness in patients with resected stage II CC diagnosed between 2010 and 2013 using the National Cancer...
Background: Rural populations of the United States have not experienced a similar degree of decline in lung cancer mortality recently seen nationwide. Several investigations examining survival differences in rural lung cancer patients have been incongruent. We investigated the association of rural residence with survival outcomes and receipt of guidelines-concordant treatment in early-stage non–small cell lung cancer (NSCLC). Methods: Retrospective study of National Cancer Data Base patients...
Purpose The aim of this study is to suggest principles for ocular procedures to be performed by allergists in their offices in helping their diagnosis of ocular diseases and suggest better interactions between allergists and ophthalmologists. Recent findings Diagnosis of ocular allergy is based on clinical history and signs and symptoms, with the support of in-vivo and in-vitro tests for the identification of the specific allergen. Unfortunately, ocular manifestations are frequently misdiagnosed...
Purpose of review In the US anterior ocular inflammatory disease (AOID) composed of the spectrum of ocular allergies, different forms of infectious conjunctivitis, and dry eye diseases, affects over 40% of the population. This review evaluates the current economic costs for AOID associated pharmacotherapies. Recent findings In recent years, with improved understanding in pathophysiology of the AOID, providing novel targets for pharmacotherapy, have led to considerable improvements in outcomes...
Journal of International Medical Research, Ahead of Print.
Journal of International Medical Research, Ahead of Print.
Summary The majority of patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) harbor a gain of function mutation V617F in Janus kinase (JAK) 2. Although JAK2 inhibitors such as ruxolitinib have been shown to be clinically efficacious, the hematological toxicity and eventual drug resistance limit its use as monotherapy. Other gene mutations or dysregulation correlated with the disease phenotype and prognosis have been found to contribute to the complexity and heterogeneity...
Summary The majority of patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) harbor a gain of function mutation V617F in Janus kinase (JAK) 2. Although JAK2 inhibitors such as ruxolitinib have been shown to be clinically efficacious, the hematological toxicity and eventual drug resistance limit its use as monotherapy. Other gene mutations or dysregulation correlated with the disease phenotype and prognosis have been found to contribute to the complexity and heterogeneity...
Related Articles[Roles and mechanism of microRNAs in the regulation of skeletal muscle insulin resistance]. Sheng Li Xue Bao. 2019 Jun 25;71(3):497-504 Authors: Zheng LF, Chen PJ, Xiao WH Abstract Insulin resistance is a common pathophysiological mechanism of obesity and type 2 diabetes mellitus. Skeletal muscle is one of the major target organs of insulin-mediated glucose uptake, metabolism and utilization, and it is the earliest and most important...
Related Articles[Role of prostaglandin E2 receptor EP4 in the regulation of adipogenesis and adipose metabolism]. Sheng Li Xue Bao. 2019 Jun 25;71(3):491-496 Authors: Yu JW, Peng J, Zhang XY, Su W, Guan YF Abstract Adipose tissue is the energy storage organ of the body, and excess energy is stored in adipocytes in the form of lipid droplets. The homeostasis of adipose tissue is the basis for the body to maintain normal metabolic activity. Prostaglandin...
Related Articles[Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury]. Sheng Li Xue Bao. 2019 Jun 25;71(3):485-490 Authors: DU YH, Ma XL Abstract The incidence and mortality rates of diabetes with cardiovascular complications are continually rising, and diabetic cardiovascular disease is becoming a major public health issue that threatens human health. Acute endothelial dysfunction and chronic cellular damage caused...
Related Articles[The cardiovascular protection of irisin and its research progress in sports field]. Sheng Li Xue Bao. 2019 Jun 25;71(3):478-484 Authors: Wang S, Liao JW, Yin HG, Ji HH, Yu H, Zou YH, Hu M Abstract Irisin is a circulating myokine induced by exercise, which is a cleaved version of fibronectin type III domain containing protein 5 (FNDC5). It can promote the browning of white fat tissue, increase energy consumption, and decrease weight....
Related Articles[Role of secretory C1q protein in the formation and regulation of synapse]. Sheng Li Xue Bao. 2019 Jun 25;71(3):471-477 Authors: Yan C, Bai J Abstract The C1q family is one of the subcomponents of the C1 complex that recognizes immune complexes and initiates the classical pathway of the complement system. In addition, as a pattern recognition receptor (PRR), the C1q family binds to a wide variety of ligands. As a member of the C1q family,...
Related Articles[The effects of anabolic-androgenic steroids on behavioral, cognitive functions and nervous systems of adolescents]. Sheng Li Xue Bao. 2019 Jun 25;71(3):463-470 Authors: Wu JM, Deng YY, Wei CQ, Yan JH Abstract Anabolic-androgenic steroid (AAS) is responsible for muscle building and masculinizing. Using AAS can enhance muscle development and strength, and improve athletic performance. AAS abuse is not only seen in sport. Research has shown...
Related Articles[Research advances in endogenous neural stem cells promoting neural repair after ischemic stroke]. Sheng Li Xue Bao. 2019 Jun 25;71(3):454-462 Authors: Fang CY, Wu XS, Zhang H, Gu YL, Wang SB, Ren HW, Chen K, Zhang H, Cheng BH, Gao Y Abstract Neural stem cell therapy, as a new therapeutic method for neural diseases, has aroused a wide concern for over 20 years since neural stem cells were first found in 1992. Ischemic stroke is highly...
Related Articles[Exosomes and their roles in neurodegenerative diseases: from pathogenic, diagnostic and therapeutical perspectives]. Sheng Li Xue Bao. 2019 Jun 25;71(3):439-453 Authors: Zhang LL, Liu MX, Xie JX, Song N Abstract Exosomes are extracellular membranous vesicles with a diameter of 30-100 nm derived from a variety of eukaryocytes. The cargo of exosomes includes proteins, lipids, nucleic acids, and substances of the cells from which they originate....
Related Articles[Effects and mechanisms of electro-acupuncture on proliferation and differentiation of neural stem cells in C57 mice exposed to different doses of X-ray radiation]. Sheng Li Xue Bao. 2019 Jun 25;71(3):431-438 Authors: Wu X, Su SH, Sun NN, Lyu MH, Zhang SJ, Gao JF Abstract The present study was aimed to investigate the effects and mechanisms of electro-acupuncture (EA) on proliferation and differentiation of neural stem cells in the hippocampus...
Related Articles[Astragaloside IV attenuates cerebral ischemia and reperfusion injury and reduces activation of NLRP3 inflammasome and NF-κB phosphorylation in rats following a transient middle cerebral artery occlusion]. Sheng Li Xue Bao. 2019 Jun 25;71(3):424-430 Authors: Tang B, Tang WJ, Tang YH, Deng CQ Abstract The present study was aimed to investigate the protective effect and anti-inflammation mechanism of astragaloside IV (AST-IV) on cerebral...
Related Articles[Wnt5a modulates vincristine resistance through PI3K/Akt/GSK3β signaling pathway in human ovarian carcinoma SKOV3/VCR cells]. Sheng Li Xue Bao. 2019 Jun 25;71(3):415-423 Authors: Wu FL, Chen HL, Hu XW, Liang LY, Xu WL Abstract The aim of this study was to investigate the effect of Wnt5a on the vincristine (VCR) resistance in human ovarian carcinoma SKOV3 cells and its possible mechanism. The drug-resistant SKOV3/VCR cells were established...
Related Articles[Expression relationship of Hippo signaling molecules and ovarian germline stem cell markers in the ovarian aging process of women and mice]. Sheng Li Xue Bao. 2019 Jun 25;71(3):405-414 Authors: Xu J, Cao XP, Tang ZJ, Huang J, Zheng YH, Li J Abstract The present study was aimed to investigate the expression relationship of Hippo signaling molecules and ovarian germline stem cell (OGSC) markers in the development schedule of OGSCs during...
Related Articles[Effects of Ramipril on the expression of connexin 43 in cerebral arteries of spontaneously hypertensive rats]. Sheng Li Xue Bao. 2019 Jun 25;71(3):395-404 Authors: Tian T, Tan CY, Jia QH, Cong WW, Tian JJ, Ma KT, Li L, Si JQ Abstract The present study was designed to examine whether Ramipril (an inhibitor of angiotensin-converting enzyme) affected spontaneous hypertension-induced injury of cerebral artery by regulating connexin 43 (Cx43)...
Related Articles[Extremely low frequency electromagnetic radiation enhanced energy metabolism and induced oxidative stress in Caenorhabditis elegans]. Sheng Li Xue Bao. 2019 Jun 25;71(3):388-394 Authors: Sun YY, Wang YH, Li ZH, Shi ZH, Liao YY, Tang C, Cai P Abstract The aim of this study was to determine the effects of extremely low frequency electromagnetic field (ELF-EMF) on energy metabolism and oxidative stress in Caenorhabditis elegans (C. elegans)....
Related ArticlesForskolin induced remodeling of lipid droplets in rat adipocytes. Sheng Li Xue Bao. 2019 Jun 25;71(3):379-387 Authors: Liu MF, DU CK, Su XY Abstract Adipose tissue is the main energy reserve of the body. When energy is required, adipocyte triglycerides stored in lipid droplets (LDs) are broken down by lipase, and free fatty acids are released to supply the physiological need. Intracellular LDs are active metabolic organelles in mammalian...
Cell competition is the elimination of one viable population of cells (the losers) by a neighboring fitter population (the winners) and was discovered by studies in the Drosophila melanogaster wing imaginal disc. Supercompetition is a process in which cells with elevated JAK/STAT signaling or increased Myc become winners and outcompete wild-type neighbors. To identify the genes that are differentially regulated in STAT supercompetitors, we purified these cells from Drosophila wing imaginal discs...
The serine protease inhibitor (serpin) gene family is the largest family of protease inhibitors. Serine protease inhibitors have an active, but under-characterised, role in grain development and defence against pathogen attack in cereal crops. By exploiting publicly available genomic, transcriptomic and proteomic data for wheat (Triticum aestivum), we have identified and annotated the entire 'serpinome' of wheat and constructed a high-quality and robust phylogenetic tree of the gene family, identifying...
Rationale: To investigate the performance of high-resolution computed tomography (HRCT) versus 18F-FDG-PET/CT for the diagnosis of pulmonary lymphangitic carcinomatosis (PLC). Methods: In this retrospective institutional approved study, ninety-four patients addressed for initial staging of lung cancer with suspicion of PLC were included. Using double blind analysis, we assessed the presence of signs favoring PLC on HRCT (smooth or nodular septal lines, subpleural nodularity, peribronchovascular...
We report on the development of the PennPET Explorer whole-body imager. Methods: The PennPET Explorer is a multi-ring system designed with a long axial field-of-view (AFOV). The imager is scalable and comprises multiple 22.9-cm long ring-segments, each with 18 detector modules based on the digital Philips Digital Photon Counting (PDPC) silicon photomultiplier. A prototype three-segment imager has been completed and tested with an active 64-cm AFOV. Results: The instrument design is described, and...
Many conflicting hypotheses regarding the relationships among crops and wild species closely related to wheat (the genera Aegilops, Amblyopyrum, and Triticum) have been postulated. The contribution of hybridization to the evolution of these taxa is intensely discussed. To determine possible causes for this, and provide a phylogeny of the diploid taxa based on genome-wide sequence information, independent data was obtained from genotyping-by-sequencing and a target-enrichment experiment that returned...
Calibrating the molecular clock is the most contentious step in every dating analysis, but the emerging total-evidence dating approach promises increased objectivity. It combines molecular and morphological data of extant and fossil taxa in a Bayesian framework. Information about absolute node ages stems from the inferred fossil placements and associated branch lengths, under the assumption of a morphological clock. We here use computer simulations to assess the impact of mismatch of the morphology...
Selective sweeps are frequent and varied signatures in the genomes of natural populations, and detecting them is consequently important in understanding mechanisms of adaptation by natural selection. Following a selective sweep, haplotypic diversity surrounding the site under selection decreases, and this deviation from the background pattern of variation can be applied to identify sweeps. Multiple methods exist to locate selective sweeps in the genome from haplotype data, but none leverage the power...
Confidence intervals (CIs) depict the statistical uncertainty surrounding evolutionary divergence time estimates. They capture variance contributed by the finite number of sequences and sites used in the alignment, deviations of evolutionary rates from a strict molecular clock in a phylogeny, and uncertainty associated with clock calibrations. Reliable tests of biological hypotheses demand reliable CIs. However, current non-Bayesian methods may produce unreliable CIs, because they do not incorporate...
Human-driven habitat fragmentation and loss has led to a proliferation of small and isolated plant and animal populations that may be threatened with extinction by genetic factors. The prevailing approach for managing these populations is to maintain high genetic diversity, which is often equated with fitness. Increasingly, this is being done using genetic rescue, where individuals from populations with high genetic diversity are translocated to small populations with high levels of inbreeding. However,...
The defining feature of the eukaryotic cell is the possession of a nucleus that uncouples transcription from translation. This uncoupling of transcription from translation depends on a complex process employing hundreds of eukaryotic specific genes acting in concert and requires the 7-methylguanylate (m7G) cap to prime eukaryotic mRNA for splicing, nuclear export, and cytoplasmic translation. The origin of this complex system is currently a paradox since it is not found or needed in prokaryotic cells...
The purpose of this research was to characterize the voice physiology requirements of indoor cycling instructors as measured by vocal dose (distance the vocal folds travel and average voice intensity) and perceived phonatory effort with and without amplification. Using a within-participant repeated measures design, eight rhythm-based cycling instructors were consented and scheduled to teach two ecologically valid cycling fitness classes, one amplified and one without amplification. Objective measures...
Under poor nutritional conditions, 3rd instar Drosophila melanogaster larvae will work collaboratively in feeding clusters to obtain resources that cannot be reached individually. To better understand the conditions that influence the expression of this behaviour we examined the frequencies, the size and the membership in vials of flies that were initially seeded with either 100 or 200 eggs each using flies from both a large, outbred population and a replicate population that was homozygous for the...
We consider a homogeneous birth-death process with incomplete sampling. Three successive sampling schemes are considered. First, individuals can be sampled through time and included in the tree. Second, they can be occurrences which are sampled through time and not included in the tree. Third, individuals reaching present day can be sampled and included in the tree. Upon sampling, individuals are removed (i.e. die). The outcome of the process is thus composed of the reconstructed evolutionary tree...
Abstract Anaerobic ammonium-oxidizing (anammox) bacteria play an essential part in nitrogen removal in constructed wetlands. The objective of the present study was to explore the spatiotemporal dynamics of anammox bacterial communities and the associated factors in a full-scale constructed wetland for the treatment of polluted surface water. The abundance and diversity of anammox bacterial communities were characterized using quantitative polymerase chain reaction (PCR) and clone...
The FDA has approved Cochlear's new Nucleus Profile Plus Series Cochlear Implant and the Nucleus 7 Sound Processor's new built-in connectivity featuring direct streaming with Android smartphones. The Nucleus Profile Plus Implant is designed for safe access to MRI scans, and allows cochlear implant users easier access to 1.5 and 3.0 Tesla MRI scans without having to remove the internal magnet or use a head wrap. The new implant is built off Cochlear's Nucleus Profile Series Implant, which maintains...
Abstract Objectives Originally developed to assess emergency preparedness, evidence suggests the Social Vulnerability Index (SVI) may also be useful to investigate multilevel environmental and social influences on health risk behaviors and outcomes. This ecological study explores the application of the SVI as a predictor of teen pregnancy rates across counties in the United States (U.S.) and identifies areas with greatest need for community-based interventions. Methods County-level...
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03707
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05696
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05192
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00344
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01217
Abstract Acute inflammatory bowel disease (AIBD) is a wide clinical entity including severe gastrointestinal pathologies with common histopathological basis. Epidemiologically increasing diseases, such as necrotizing enterocolitis (NEC), gastrointestinal graft versus host disease (GVHD), and the primary acute phase of chronic inflammatory bowel disease (CIBD), exhibit a high necessity for new therapeutic strategies. Mesenchymal stem cell (MSC) cellular therapy represents a promising...
Abstract Cushing's disease (CD) is most commonly caused by a microadenoma, which at surgical exploration may not provide adequate tissue for pathologic diagnosis using standard techniques. We wished to determine the accuracy of intraoperative pathologic examination and whether the addition of intraoperative cytology increased the diagnostic yield. We reviewed the pathology reports from 403 operations on 341 patients with CD microadenomas from a single institution. The concordance...
A decade ago, the mixed reproductive strategy Asexual Queen Succession (AQS) was first described in termites. In AQS species, the workers, soldiers and dispersing reproductives are produced through sexual repr...
The emergence of antimicrobial-resistant (AMR) strains of the important human and animal pathogen Salmonella enterica poses a growing threat to public health. Here, we studied the genome-wide evolution of 90 S. e...
A decade ago, the mixed reproductive strategy Asexual Queen Succession (AQS) was first described in termites. In AQS species, the workers, soldiers and dispersing reproductives are produced through sexual repr...
The emergence of antimicrobial-resistant (AMR) strains of the important human and animal pathogen Salmonella enterica poses a growing threat to public health. Here, we studied the genome-wide evolution of 90 S. e...
The aim of this study is to assess the quality of life of caregiver's. The study was conducted at the RABAT National Institute of Oncology in MOROCCO.
The aim of this study was to examine the effects of walking at different speeds while using a mobile phone on spatiotemporal stride parameters among young adults. Ten participants (7 male, 3 female; age = 24.7...
An integrated cell manipulation platform is developed for use in conjunction with a single-probe mass spectrometry setup for the on-line analysis of individual suspension cells under ambient conditions.
We describe methods for presenting real-world objects and matched images of the same objects under tightly-controlled experimental conditions. The methods are described in the context of a decision-making task, but the same real-world approach can be extended to other cognitive domains such as perception, attention, and memory.
Application of virtual reality (VR) to rehabilitation is relatively recent with clinical implementation very rapidly following technological advancement and scientific discovery. Implementation is often so rap...
Prenatal antibiotic exposure has been associated with an altered infant gut microbiome composition and higher risk of childhood obesity, but no studies have examined if prenatal antibiotics simultaneously alte...
Here we present a protocol to induce severe TBI with the lateral fluid percussion injury (FPI) model in adult, male Wistar rats. We also demonstrate the use of a wireless telemetry system to collect continuous video-EEG recordings and monitor for epileptiform discharges consistent with post-traumatic epileptogenesis.
l-Cysteine (Cys) is metabolically fundamental sulfur compound and important components in various cellular factors. Interestingly, free-form Cys itself as a simple monomeric amino acid was recently shown to fun.....
Fluridone is widely used as a herbicide for controlling invasive aquatic plants such as hydrilla in surface water bodies. When applied on surface waters fluridone can attach to bed sediment, requiring rigorous ex...
Nature, Published online: 21 June 2019; doi:10.1038/d41586-019-01974-1Cuttlefish, spiders and human deploy the same genes despite evolving limbs independently. Plus: meet the Ebola workers battling a virus in a war zone and learn how to do fieldwork with kids in tow.
Abstract Background Infants who are iron-deficient anemic seek and receive less stimulation from their caregivers, predisposing such children to be functionally isolated. Objectives To test the sequence whereby iron deficiency in infancy contributes to children's disengagement from the environment, which reduces parent stimulation which, in turn, contributes...
Abstract Objectives To explore factors that shape decisions made regarding employee benefits and compare the decision-making process for workplace breastfeeding support to that of other benefits. Methods Sixteen semi-structured, in-depth interviews were conducted with Human Resource Managers (HRMs) who had previously participated in a breastfeeding-support survey. A priori codes were used, which were based on a theoretical model informed by organizational behavior theories, followed...
Introduction The presence of structural in‐series continuity between skeletal muscles has been confirmed in the trunk and lower extremity. However, it is not yet clear whether the same architecture can be found in the upper limb. Therefore, the aim of the present study was to review the available literature considering the existence of myofascial chains in the shoulder‐arm region. Materials and Methods Two independent investigators performed a systematic literature search using MEDLINE (PubMed)...
Abstract Purpose Transfusion-dependent beta-thalassemia (TDT) patients suffer from various endocrinopathies. The main contributing factor associated with these complications is iron overload, secondary to frequent blood transfusions. To improve patients' quality of life, we evaluated the prevalence of endocrine disorders while considering the associated factors for further assessment. ...
Perineural invasion is an aggressive phenotype for head and neck squamous cell carcinomas and other tumors. The chick chorioallantoic membrane model has been used for studying angiogenesis, cancer invasion, and metastasis. Here we demonstrate how this model can be utilized to assess perineural invasion in vivo.
Here we present a sensitive, rapid, and discriminating post-gel staining method to image RNAs tagged with RNA Mango aptamers I, II, III, or IV, using either native or denaturing polyacrylamide gel electrophoresis (PAGE) gels. After running standard PAGE gels, Mango-tagged RNA can be easily stained with TO1-Biotin and then analyzed using commonly available fluorescence readers.
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00435
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00681
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00968
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02224
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01293
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b04412
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b04755
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b02947
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03155
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05476
Leser–Trélat syndrome, which manifests as eruptive multiple seborrheic keratoses, is a rare paraneoplastic sign. Hyponatremia in the elderly population is an often overlooked but potentially sinister biochemic...
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