Pharmaceutics, Vol. 11, Pages 615: Efficient Delivery of Therapeutic siRNA by Fe3O4 Magnetic Nanoparticles into Oral Cancer CellsPharmaceutics, Vol. 11, Pages 615: Efficient Delivery of Therapeutic siRNA by Fe3O4 Magnetic Nanoparticles into Oral Cancer Cells Pharmaceutics doi: 10.3390/pharmaceutics11110615 Authors: Lili Jin Qiuyu Wang Jiayu Chen Zixiang Wang Hongchuan Xin Dianbao Zhang The incidence of oral cancer is increasing due to smoking, drinking, and human papillomavirus (HPV) infection, while...
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Nutrients, Vol. 11, Pages 2809: Oxidative Status before and after Renal Replacement Therapy: Differences between Conventional High Flux Hemodialysis and on-Line HemodiafiltrationNutrients, Vol. 11, Pages 2809: Oxidative Status before and after Renal Replacement Therapy: Differences between Conventional High Flux Hemodialysis and on-Line Hemodiafiltration Nutrients doi: 10.3390/nu11112809 Authors: Navarro-García Rodríguez-Sánchez Aceves-Ripoll Abarca-Zabalía Susmozas-Sánchez Lafuente Bada-Bosch Hernández...
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Surgical/Orthodontic Correction of Transverse Maxillary DiscrepanciesPublication date: Available online 4 November 2019Source: Oral and Maxillofacial Surgery Clinics of North AmericaAuthor(s): Johan P. Reyneke, Richard Scott ConleyOrthodontics for the Oral and Maxillofacial Surgery PatientPublication date: Available online 4 November 2019Source: Oral and Maxillofacial Surgery Clinics of North AmericaAuthor(s): Michael R. Markiewicz, Veerasathpurush Allareddy, Michael MiloroInterceptive Dentofacial...
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Guest editorial of the IJCARS–JAMIT 2017–2018 special issueDesigning and validating a PVA liver phantom with respiratory motion for needle-based interventionsAbstractPurposeThe purpose is to design and validate an anthropomorphic polyvinyl alcohol (PVA) liver phantom with respiratory motion to simulate needle-based interventions. Such a system can, for example, be used as a validation tool for novel needles.MethodsImage segmentations of CT scans of four patients during inspiration and expiration...
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Structural organization, GABAergic and tyrosine hydroxylase expression in the striatum and globus pallidus of the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)AbstractThe striatum is an essential component of the basal ganglia that regulatessensory processing, motor, cognition, and behavior. Depending on the species, the striatum shows a unique structure called caudate–putamen as in mice, or its separation into two regions called caudate and lenticular nuclei, the latter...
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Book Review: Beyond Greenwash? Explaining Credibility in Transnational Eco-Labeling, by Hamish van der VenConsumer Policy in 28 EU Member States: An Empirical Assessment in Four DimensionsAbstractThis article examines consumer policy in 28 EU Member States. It introduces a new methodological framework and several indicators to analyse legal, social, enforcement, and associational dimensions of consumer policy. Drawing on the most recent data, the empirical results provide a detailed picture of consumer...
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Structural-functional characterization of recombinant Apolipoprotein A-I from Labeo rohita demonstrates heat-resistant antimicrobial activityAbstractApolipoprotein A-I is an anti-inflammatory, antioxidative, cardioprotective, anti-tumorigenic, and anti-diabetic in mammals. Apolipoprotein A-I also regulates innate immune defense mechanisms in vertebrates and invertebrates. Apolipoproteins A-I from mammals and several teleosts display antibacterial activities against Gram negative and Gram positive...
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Coping, Attributions, and Health Functioning Among Adolescents with Chronic Illness and Their Parents: Reciprocal Relations Over TimeAbstractThe purpose of the study was to identify bidirectional and longitudinal links between attributions, coping, and health functioning among adolescents with chronic illness and their parents. Religious/spiritual coping, attributional styles, and health functioning were assessed among adolescents with chronic illness at two time points approximately 21 months apart....
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Pseudoplagiostoma myracrodruonis (Pseudoplagiostomataceae, Diaporthales): a new endophytic species from BrazilAbstractTwo initially unidentifiable isolates were found when endophytic fungi from healthy leaves of Myracrodruon urundeuva (Anacardiaceae) were being investigated in Brazil. Based on phylogenetic analyses using internal transcribed spacer (ITS) and partial large subunit (LSU) of ribosomal DNA, RNA polymerase II (RPB2), translation elongation factor EF-1 alpha (TEF1), and tubulin (TUB2),...
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Relationships Between Dry-land Resistance Training and Swim Start Performance and Effects of Such Training on the Swim Start: A Systematic ReviewNo sources of funding were used in the preparation of this article.Correction to: Injury Incidence, Prevalence and Severity in High-Level Male Youth Football: A Systematic ReviewFirst Key Point, sentence 2, which previously read:Sex Dimorphism of VO 2max Trainability: A Systematic Review and Meta-analysisAbstractBackgroundIncreases in maximal oxygen uptake...
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A New Generation of Drug Users in St. Petersburg, Russia? HIV, HCV, and Overdose Risks in a Mixed-Methods Pilot Study of Young Hard Drug UsersAbstractRussia has a widespread injection drug use epidemic with high prevalence of HIV and HCV among people who inject drugs (PWID). We conducted a mixed methods study of young (age 18–26) hard drug users in St. Petersburg. Thirty-nine structured and 10 semi-structured interviews were conducted. No HIV cases and two HCV cases were detected among the PWID subsample...
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A Comparative Analysis of Forest Fire Risk Zone Mapping Methods with Expert KnowledgeAbstractDespite repeated occurrences of forest fire, very less scientific studies have been reported in the Indian context especially in Kudremukh region to mitigate and suppress the fire. The objective of this article was to pool the expert knowledge on forest fire triggering factors from officials working in wildlife division in the Western Ghats of India through a questionnaire and to validate the risk zones obtained...
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Role of regulatory T cells and checkpoint inhibition in hepatocellular carcinomaAbstractImmune checkpoint inhibition suggests promising progress for the treatment of advanced hepatocellular carcinoma (HCC). However, the underlying cellular mechanisms remain unclear because liver cancer cells apparently do not upregulate inhibitory checkpoint molecules. Here, we analysed whether regulatory T cells (Tregs) can alternatively trigger checkpoint inhibition pathways in HCC. Using flow cytometry we analysed...
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Functional Dyspepsia in the ElderlyAbstractPurpose of ReviewFunctional dyspepsia is a common condition, and the condition is defined by symptoms using Rome IV criteria. This review addresses the issue of functional dyspepsia in elderly patients, epidemiology, investigation, and treatment.Recent FindingsRecent studies show that while the prevalence of dyspepsia declines in the elderly, it is still prevalant investigations to confirm the diagnosis (including mandatory upper gastrointestinal endoscopy)...
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Keto microbiota: A powerful contributor to host disease recoveryAbstractGut microbiota (GM) is a key contributor to host metabolism and physiology. Data generated on comparing diseased and healthy subjects have reported changes in the GM profile between both health states, suggesting certain bacterial composition could be involved in pathogenesis. Moreover, studies reported that reshaping of GM could contribute actively to disease recovery. Interestingly, ketogenic diets (KD) have emerged recently...
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Exploring the Relationship Between Lasting, Quality Social Bonds and Intermittency in OffendingThe original version of this article, unfortunately, was missing a decimal point in Table 2. The effect size (b) for Proportion of Time on the Street in Waves 1–6 should be −2.403 instead of −2403.Self-Reported Male-Female Differences in Criminal Involvement Do Not Account for Criminal Justice Processing DifferencesAbstractDisparities between males and females in criminal behavior have been widely documented....
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Burn and plug: is it too much for the left atrial appendage?Peri-procedural use of direct anticoagulation agents during cardiac device implantation: vitamin K antagonists vs direct oral anticoagulantsAbstractBackgroundWarfarin is deemed safe compared to bridging with heparin in the peri-procedure setting while implanting cardiac devices. The timing of discontinuation and re-initiation of direct anticoagulant agents (DOACs) such as dabigatran, apixaban, and rivaroxaban in the peri-procedural setting...
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Molecular Characterization of Coxsackievirus B5 Isolates from Sewage, Italy 2016–2017AbstractHereby, the partial Viral Protein 1 sequences of Coxsackievirus B5 (CV-B5) from sewage samples, collected in Italy from 2016 to 2017, were compared with those available in GenBank from clinical samples. Phylogenetic analysis highlighted: (I) the predominant circulation of CV-B5 genogroup B in Italy, and (II) the presence of two new sub-genogroups.Characterization of Norovirus and Other Human Enteric Viruses...
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A Comparison Between the TEG® 6s and TEG® 5000 Analyzers to Assess Coagulation in Trauma PatientsBackground Trauma-induced coagulopathy is a major driver of mortality following severe injury. Viscoelastic goal-directed resuscitation can reduce mortality after injury. The TEG® 5000 system is widely used for viscoelastic testing. However, the TEG® 6s system incorporates newer technology, with encouraging results in cardiovascular interventions. The purpose of this study was to validate the TEG® 6s...
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"This institution was never meant for me": the Impact of Institutional Historical Portraiture on Medical StudentsWho Orders Screening Mammograms in Older Women with Limited Life Expectancy?More Information Needed on Probiotic Supplement Product LabelsQuality of Mental Health Care in Integrated Veterans Affairs Patient-Centered Medical Homes: a National Observational StudyThe Relationship Between Federal Housing Assistance and Uptake of Cancer Screening Among Low-Income AdultsA Phone CallRacial and...
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"This institution was never meant for me": the Impact of Institutional Historical Portraiture on Medical StudentsWho Orders Screening Mammograms in Older Women with Limited Life Expectancy?More Information Needed on Probiotic Supplement Product LabelsQuality of Mental Health Care in Integrated Veterans Affairs Patient-Centered Medical Homes: a National Observational StudyThe Relationship Between Federal Housing Assistance and Uptake of Cancer Screening Among Low-Income AdultsA Phone CallRacial and...
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Wood protective coatings based on fluorocarbosilaneAbstractThe effectiveness of protective coatings based on 3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)propyltriethoxysilane in the protection of wood surface from the effects of water was tested. No earlier attempts at using the mentioned fluorocarbosilane for the protection of wood have been reported in the literature. The coatings were deposited by the sol–gel method. As a result of the generation of chemical bonds between the wood surface and silane,...
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The Dyadic Experience of Managing Heart Failure: A Qualitative InvestigationBackground: Self-management of heart failure (HF) is often a joint venture between patients and their friends and family ("framily"). However, this joint experience is often overlooked in clinical care. Objectives: The aim of this study was to understand the cognitive, emotional, and relational elements affecting the experience of patient-framily member dyads managing HF. Methods: Participants were patients with HF receiving...
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Trypanosoma cruzi and hematospermia,Liraglutide promotes autophagy by regulating the AMPK/mTOR pathway in a rat remnant kidney model of chronic renal failureAbstractBackgroundWe aimed to determine whether the glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide (LRG) could ameliorate renal function through promoting autophagy via regulating the AMPK/mTOR pathway in a rat remnant kidney model of chronic renal failure.MethodsRats were divided into four groups (n = 10 per group) as follows:...
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NAVA and PAV+ for lung and diaphragm protectionPurpose of review Complications of mechanical ventilation, such as ventilator-induced lung injury (VILI) and ventilator-induced diaphragmatic dysfunction (VIDD), adversely affect the outcome of critically ill patients. Although mostly studied during control ventilation, it is increasingly appreciated that VILI and VIDD also occur during assisted ventilation. Hence, current research focuses on identifying ways to monitor and deliver protective ventilation...
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Desert, Control, and Moral ResponsibilityAbstractIn this paper, I take it for granted both that there are two types of blameworthiness—accountability blameworthiness and attributability blameworthiness—and that avoidability is necessary only for the former. My task, then, is to explain why avoidability is necessary for accountability blameworthiness but not for attributability blameworthiness. I argue that what explains this is both the fact that these two types of blameworthiness make different...
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Unexpected response of extramedullary plasmacytoma in patients with lung cancer who received nivolumabCorrection to: prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuriaThe authors determined an error in the affiliation section; it was captured as Department of Hematology, Peking Union Hospital, CAMS & PUMC, Beijing 100,730, China. The correct affiliation should be Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science...
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Trypanosoma cruzi and hematospermia,Liraglutide promotes autophagy by regulating the AMPK/mTOR pathway in a rat remnant kidney model of chronic renal failureAbstractBackgroundWe aimed to determine whether the glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide (LRG) could ameliorate renal function through promoting autophagy via regulating the AMPK/mTOR pathway in a rat remnant kidney model of chronic renal failure.MethodsRats were divided into four groups (n = 10 per group) as follows:...
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Monogalactosyldiacylglycerols with High PUFA Content From Microalgae for Value-Added ProductsAbstractMonogalactosyldiacylglycerols (MGDGs) from microalgae containing a high proportion of polyunsaturated fatty acids (PUFAs) have enormous potential applications in various industries. In this study, the productivity and fatty acid composition of MGDGs from three microalgae in commercialized production, Chlorella sorokiniana GT, Nannochloropsis oceanica IMET1, and Arthrospira platensis, were evaluated...
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Correction to: Rethinking Critique: Becoming ClinicianThe article Rethinking Critique: Becoming Clinician, written by Leticia Da Costa Paes, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 24 September 2019 with open access.Catastrophe: IntroductionFrom Cairo to Jerusalem: Law, Labour, Time and CatastropheAbstractFollowing the eclectic itineraries of 'Near East' expert, R. M. Graves, this article tells a story of an ongoing Nakba (catastrophe)...
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Experimental Investigation on Permeability Evolution of Limestone Caprock under Coupled THM ProcessesAbstractTo investigate the gas sealing capacity of limestone as cap rock for gas reservoir at different burial depths, triaxial compression coupled with permeability tests of limestone subjected to different confining pressures and temperatures were carried out using the improved MTS 815 test machine. During the tests, acoustic emission (AE) monitoring system was also employed to estimate the rock...
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Gangs in the El Paso-Juárez borderland: the role of history and geography in shaping criminal subculturesAbstractThis paper examines the early precursors of organized criminal subcultures using the U.S.-Mexico border city of El Paso, Texas as a case-study. El Paso is known as the birthplace of the pachuco; the Mexican Americans' original street-oriented subculture. It formed the basis for the numerous delinquent groups that would emerge there throughout the decades, ultimately producing a binational...
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Simulation and Architecture: Mapping Building Information ModelingAbstractIn the 1990s, Building Information Modeling (BIM) software significantly altered architectural approaches to planning and building. Based on parametric methods, BIM technologies sought to simulate the construction process prior to a building's realisation. These computer simulations challenged the existing practice of representing a building through plan, section and elevation, proposing that one computational model could create...
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George R. Schwarz: The Steamboat Phoenix and the Archaeology of Early Steam Navigation in North AmericaPeter Holt: The Resurgam Submarine: 'A Project for Annoying the Enemy'Capacity in Maritime Archaeology: A Framework for AnalysisAbstractCapacity development is a key tool that can be used to improve maritime archaeological research and underwater cultural heritage protection. Despite numerous capacity development initiatives there has been little written about the theoretical concept of capacity...
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Use of Health Technologies for Low Back Pain in the Military Health SystemAbstractLow back pain (LBP) is a widespread condition that poses specific occupational risks for active-duty military personnel. Barriers to treatment are also greater for military personnel and veterans. The authors conducted a review of the literature to identify technology solutions to help offset barriers to treatment for military personnel and veterans. Researchers conducted a PubMed search using subject headings and natural...
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Theoretical study of formate, tartrate, tartronate, and glycolate production from 6-carbon trioxylate intermediate in the citric acid cycleAbstractReaction pathways of side products (formate, glycolate, and tartronate) from dihydroxyfumarate (DHF) were theoretically investigated as DHF is an intermediate in the process of producing tartrates and oxalate from glyoxylate of the citric acid cycle. The proposed pathways for each reaction were mapped by density functional theory (DFT) calculations. The...
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Letter to the editors: comment on "Dissociation of caloric and head impulse tests: a marker of Meniere's disease"Eighty years of Medication-Overuse Headache: what about Medication-Overuse Backpain?AbstractIntroductionAlthough chronic low back pain (CLBP) is one of the most common pain syndromes, up to now, clear pathophysiological causes or specific treatment options are missing. Medication-overuse has been associated with chronic headache, but never with CLBP.HypothesisBased on several similarities...
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Pemphigus Vulgaris From the Editor Triage of Two Cultures The night the Queens sky exploded Do No...
Pemphigus VulgarisFrom the EditorTriage of Two CulturesThe night the Queens sky explodedDo No Harm: Exposing the Hippocratic Hoax, directed by Robyn Symon, 2018The Donor Letter Project: Learning Professionalism and Fostering Empathy in an Anatomy CurriculumAbstractWhile cadaver dissection remains an unmatched learning tool for structural anatomy, recent shifts in medical culture and pedagogy indicate that developing humanistic practices and fostering empathic responses are crucial components of early...
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Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cellsA single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alterationC9orf72 -specific phenomena associated with frontotemporal dementia and gastrointestinal symptoms in the absence of TDP-43 aggregationMSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvementAbstractMSTO1 encodes a cytosolic mitochondrial fusion protein, misato...
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