Generalized morphea in the setting of pembrolizumab

International Journal of Dermatology, EarlyView.


https://ift.tt/2ltfQV8

Trigeminal trophic syndrome: an updated review

International Journal of Dermatology, EarlyView.


https://ift.tt/2yJP9om

A giant mass on the scalp: an unusual presentation of lupus vulgaris

International Journal of Dermatology, EarlyView.


https://ift.tt/2luLAJj

Infantile Hemangioma Presenting as Colocolic Intussusception in an Infant Case Report with Review of Pathologic Lead Points

Infantile hemangioma (IH) is one of the most common vascular anomalies of early childhood and is usually recognized in the first few weeks to months of life as a solitary cutaneous lesion. This report documents our experience with a GLUT-1 positive IH presenting as the pathologic lead point in a colocolic intussusception in a 10-week-old infant who had no skin lesions. Literature suggests approximately 2% of all children presenting with an intussusception require surgical intervention; however, an IH as the pathologic lead point is unique.

https://ift.tt/2ImhYa8

Efficient decellularization of rabbit trachea to generate a tissue engineering scaffold biomatrix

Publication date: September 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 112
Author(s): Paul Hong, Michael Bezuhly, M. Elise Graham, Paul F. Gratzer
ObjectivesMost tracheal decellularization protocols are lengthy and can lead to reduced biomechanical stability. The objectives of this study were: 1) to generate a tracheal extracellular matrix scaffold using an efficient decellularization process and 2) to characterize the decellularized scaffold to assess its suitability for tissue engineering applications.MethodsTwelve rabbit tracheae underwent a decellularization process that involved enzymatic-detergent treatments. For characterization, fresh (control) and decellularized tissues underwent histological, immunohistochemical, and biochemical analyses. Tensile testing, scanning electron microscopy, and biocompatibility assay were also conducted.ResultsPost-decellularization, the tracheal tissue had significantly less genetic material while the structural integrity was maintained. Specifically, the deoxyribonucleic acid content was significantly reduced and the glycosaminoglycan content was unchanged. Cell and cellular components were largely removed; at the same time the tensile properties and surface ultrastructural characteristics were unaltered. Biocompatibility was confirmed by contact cytotoxicity assay.ConclusionsOverall, an efficient decellularization process was used to treat rabbit tracheal tissue. The effectiveness of the decellularization process was demonstrated and at the same time there was preservation of the underlying extracellular matrix structure. This decellularized material may serve as a potential scaffold for tracheal tissue engineering.



https://ift.tt/2yCapwp

Erratum to “Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor”

https://ift.tt/2MlzrSB

Validation and assessment of discordance of the 8th edition AJCC (American Joint Committee on Cancer) clinical and pathologic staging systems in patients with p16+ oropharyngeal cancer treated with surgery and adjuvant radiation at a single institution

Publication date: August 2018
Source:Oral Oncology, Volume 83
Author(s): Piyush Gupta, Jocelyn C. Migliacci, Ashley Hay, Matthew Rosenthal, Ximena Mimica, Nancy Lee, Richard J. Wong, Jatin Shah, Snehal Patel, Ian Ganly




https://ift.tt/2yAwc7R