An International Standard for holotranscobalamin (holoTC): international collaborative study to assign a holoTC value to the International Standard for vitamin B12 and serum folate

Authors: Thorpe, Susan J. / Rigsby, Peter / Roberts, Graham / Lee, Anne / Hamilton, Malcolm / Craig, David


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Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases

Authors: Magni, Paolo / Macchi, Chiara / Sirtori, Cesare R. / Corsi Romanelli, Massimiliano Marco


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BRAF analysis before surgery for papillary thyroid carcinoma: correlation with clinicopathological features and prognosis in a single-institution prospective experience

Authors: Galuppini, Francesca / Pennelli, Gianmaria / Vianello, Federica / Censi, Simona / Zambonin, Laura / Watutantrige-Fernando, Sara / Manso, Jacopo / Nacamulli, Davide / Lora, Ornella / Pelizzo, Maria Rosa / Rugge, Massimo / Barollo, Susi / Mian, Caterina


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Raman Spectroscopic Characterization of Packaged L. pneumophila Strains Expelled by T. thermophila

Analytical Chemistry

DOI: 10.1021/acs.analchem.5b04699

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Welding, a risk factor of lung cancer: the ICARE study

Objectives

We investigated the relationship between lung cancer and occupational exposure to welding activity in ICARE, a population-based case–control study.

Methods

Analyses were restricted to men (2276 cases, 2780 controls). Welding exposure was assessed through detailed questionnaires, including lifelong occupational history. ORs were computed using unconditional logistic regression, adjusted for lifelong cigarette smoking and occupational exposure to asbestos.

Results

Among the regular welders, welding was associated with a risk of lung cancer (OR=1.7, 95% CI 1.1 to 2.5), which increased with the duration (OR=2.0, 95% CI 1.0 to 3.9 when duration >10 years), and was maximum 10–20 years since last welding. The risk was more pronounced in case of gas welding (OR=2.0, 95% CI 1.2 to 3.3), when the workpiece was covered by paint, grease, or other substances (OR=2.0, 95% CI 1.2 to 3.4) and when it was cleaned with chemical substances before welding. No statistically significant increase in lung cancer risk was observed among occasional welders.

Conclusions

Although these results should be confirmed, we showed that type of welding and mode of workpiece preparation are important determinants of the lung cancer risk in regular welders.

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Second to Fourth Digit Ratios in Plastic Surgery

No abstract available

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Identification of a founder BRCA1 mutation in the Moroccan population

Abstract

Breast cancer (BC) is the most frequent cancer among women in Morocco. However, the role of the most prevalent BC-predisposing genes, BRCA1 and BRCA2, has been largely unexplored. To help define the role of BRCA1 in breast cancer in Morocco, we characterized the first potential BRCA1 founder mutation in this population. Genetic testing of BRCA1 and BRCA2 in BC high-risk families identified mutation BRCA1 c.5309G>T, p.(Gly1770Val) or G1770V in five independent families from Morocco, suggesting a founder effect. To confirm this hypothesis, haplotype construction was performed using seven intragenic and flanking BRCA1 microsatellite markers. Clinical data were also compiled. Clinical data from carriers of mutation G1770V correspond to data from carriers of BRCA1 pathogenic mutations. Microsatellite analysis showed a common haplotype for the five families in a region comprising 1.54Mb, confirming G1770V as the first specific founder BRCA1 mutation in the Moroccan population.

Our findings contribute to a better understanding of BC genetics in the Moroccan population. Nevertheless, comprehensive studies of mutation G1770V in large series of BC patients from Morocco are needed to assess the real prevalence of this mutation and to improve genetic testing and risk assessment in this population.

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