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Δευτέρα 7 Δεκεμβρίου 2015

Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract

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The site-specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising activity relative to the native enzyme. The importance of polymer attachment sites is investigated, as well as the significance of polymer structure.



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