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Δευτέρα 21 Δεκεμβρίου 2015

Specific self-monitoring of metal-associated amyloid-[small beta] peptide disaggregation by a fluorescent chelator

GA?id=C5CC08898D

Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5CC08898D, Communication
Tao Yang, Xiaohui Wang, Changli Zhang, Xiang Ma, Kun Wang, Yanqing Wang, Jian Luo, Liu Yang, Cheng Yao, Xiaoyong Wang
A dual-functional fluorescent chelator can specifically target and disassemble metal-associated A[small beta] aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.
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