Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients

Abstract

Trichodysplasia spinulosa (TS) is a rare skin disease occurring in immunocompromised patients, caused by a specific polyomavirus. Pathophysiological mechanisms of TS are not yet fully understood. We report evidence of follicular keratinocytes being the primary target of trichodysplasia spinulosa-associated polyomavirus (TSPyV) by PCR and skin biopsy immunostaining in a pædiatric case.

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