Objective: Prokinetic medications are used in premature infants to promote motility and decrease time to full enteral feeding. Erythromycin and metoclopramide are the most commonly used prokinetic medications in the neonatal intensive care unit (NICU), but their safety profile is not well defined. Methods: We conducted a large retrospective cohort study using data from 348 NICUs managed by the Pediatrix Medical Group. All of the infants exposed to ≥1 dose of erythromycin, metoclopramide, or both, from a cohort of 8,87,910 infants discharged between 1997 and 2012 were included. We collected laboratory and clinical information while infants were exposed to erythromycin or metoclopramide and described the frequency of laboratory abnormalities and clinical adverse events (AEs). Results: Metoclopramide use increased from 1997 to 2005 and decreased from 2005 to 2012, whereas erythromycin use remained stable. Erythromycin use was most often associated with a diagnosis of feeding problem (40%), whereas metoclopramide was most often associated with a diagnosis of gastroesophageal reflux (59%). The most common laboratory AE during exposure to erythromycin or metoclopramide was hyperkalemia (8.6/1000 infant days on erythromycin and 11.0/1000 infant days on metoclopramide). Incidence of pyloric stenosis was greater with erythromycin than with metoclopramide (10/1095, 0.9% vs 76/19,001, 0.4%; P = 0.01), but odds were not significantly increased after adjusting for covariates (odds ratio 0.52, 95% confidence interval [CI] 0.26–1.02, P = 0.06). More infants experienced an AE while treated with metoclopramide than with erythromycin (odds ratio 1.21, 95% CI 1.03–1.43). Conclusions: Metoclopramide was associated with increased risk of AEs compared with erythromycin. Studies are needed to confirm safety and effectiveness of both the drugs in infants.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1LRYGU3
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
►
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
▼
2015
(1500)
-
▼
Δεκεμβρίου
(1450)
-
▼
Δεκ 04
(33)
- Evaluation of Serum Interleukin-17 (IL-17) Levels ...
- GLYX-13 (rapastinel) ameliorates subchronic phency...
- Abdel El Manira elected in the Royal Swedish Acade...
- Social Media and Scientific Meetings:
- PLCζ disruption with complete fertilization failur...
- Between compliance and resistance: exploring disco...
- Induction for intrahepatic cholestasis of pregnanc...
- Nutrition-dependent phenotypes affect sexual selec...
- Prey consumption by phytoseiid spider mite predato...
- Application of small molecules favoring naive plur...
- Genetic differentiation in native and introduced p...
- Genome sequence of the Asian Tiger mosquito, Aedes...
- Nanocomposite versus Mesocomposite for Osteogenic ...
- Paediatric anaesthesia emergency data manual
- Tramadol-induced hyperalgesia and its prevention b...
- The kalaemic and neuromuscular effects of succinyl...
- Persistent posthysterectomy pain: A prospective, o...
- Response to rocuronium and its determinants in pat...
- Failure of sugammadex to reverse rocuronium-induce...
- Efficacy and safety of sugammadex in the reversal ...
- Can residual paralysis be avoided?: A critical app...
- Predictors of the variability in neuromuscular blo...
- Chronic postsurgical pain in Europe: An observatio...
- General anaesthetic agents do not influence persis...
- Neostigmine dose: Comparison between theory and pr...
- Preoperative glycosylated haemoglobin as a predict...
- Shoulder pain after hepatectomy occurs more freque...
- Prevalence, characteristics and risk factors of ch...
- Intraoperative temperature monitoring with zero he...
- Use and Safety of Erythromycin and Metoclopramide ...
- Overuse of the Emergency Department and CT Scans i...
- Infliximab More Effective in Therapy-Naïve Than in...
- Portopulmonary Hypertension: Opportunities for Pre...
-
▼
Δεκ 04
(33)
-
▼
Δεκεμβρίου
(1450)
Ετικέτες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου