Early and late vulval cancer recurrences: Are they different?

Early and late vulval cancer recurrences: Are they different?

J Obstet Gynaecol. 2016 Jan 22;:1-4

Authors: Ragupathy K, Grandidge L, Strelley K, Wang H, Tidy J

Abstract
Vulval cancers are rare, but after primary treatment, known to recur with a high frequency (30%). Clinico-pathological predictors of recurrence have been established to a great extent. However, there is paucity of literature on predictors of early versus late recurrence. We sought to identify such predictors through a retrospective study of vulval cancer recurrences in a single cancer centre over 11 years. Age of women, depth of invasion/site of primary tumour and presence of background VIN/lichen sclerosus do not appear to affect timing of recurrence. However, vulval cancers that recur after 2 years of primary tumour recognition are more likely to be well-differentiated tumours, have undergone radical surgery and have had a closest disease-free margin >1 cm. Late recurrences are entirely local rather than distant metastases and this translates into a better survival as shown in our study (40 months median survival in the early group versus 112 in the late recurrence group).

PMID: 26800292 [PubMed - as supplied by publisher]

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