With great interest we read the recent publication from Vinter and colleagues describing the role of TNFα in the Aldara model1. Through the use of scoring skin inflammation, RT-PCR, and histology, they showed that TNFα-deficient mice showed less erythema, scaling, epidermal hyperplasia, Ki67, CD3+ T cells staining and splenomegaly. The authors continued by quantifying several mediating cytokines, such as IL-17A, IL-22, IL-12p40, and IL-23p19; which were significantly reduced in TNFα-knockouts.
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