Effect of change in sequence of administration of DTwP and Hepatitis B vaccines on perception of pain in infants: A randomized control trial

Publication date: Available online 20 February 2016
Source:Vaccine
Author(s): Mithilesh Kumar, Amit Upadhyay, Jeevika Singh, Manika Chhabra, Abhishek Singh, Navratan Kumar Gupta, Aditya Bhat, C.P. Yadav
ObjectiveThis study was designed with objective to study pain response of infants to change in sequence of administration of Hepatitis B and DTwP vaccines.MethodsThis was a randomized parallel control trial. The study was carried out in the immunization clinic of the Department of Pediatrics, LLRM Medical College, Meerut. One hundred and thirty healthy term infants up to 4 months of age were injected either DTwP vaccine first or Hepatitis B vaccine first, followed one minute later by the other vaccine.ResultBaseline characteristics did not differ between the groups. The mean (SD) of AUC of MFCS and NIPS was significantly more in DF group as compared to HF group (for MFCS 25.5±5.4 versus 22.5±5.5, p<0.01; for NIPS 31.77±5.5 versus 27.64±6.9, p<0.01). Similarly mean (SD) of AUC of Heart rate and saturation of oxygen showed significant variation in DF group as compared to HF group (for heart rate 591.6±55 versus 559.6±49, p<0.01; for SpO2 326.4±12 versus 335±8, p<0.01).ConclusionThese results showed that infant experienced lesser pain when Hepatitis B was administered first than when DTwP vaccine was given first.



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