The Use of Immunohistochemistry in Detection of Perineural Invasion in Mucoepidermoid Carcinoma

Publication date: Available online 13 February 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Emily Lanzel, Robert A. Robinson, M.B. Zimmerman, Ali Pourian, John W. Hellstein
ObjectivesTo retrospectively study the prevalence of perineural invasion (PNI) in cases of mucoepidermoid carcinoma (MEC). The study evaluated if previously assessed PNI by original pathology reports would be increased by re-review of the originally hematoxylin-eosin-stained (H&E) slides as well as review of slides reacted immunohistochemically with S100 to enhance nerve visualization and whether is associated with clinical outcome.Study DesignThirty-one cases were reviewed for PNI with H&E stained slides as well as S-100 reacted slides. These results were compared to the original pathology report's PNI status when available (13/31). Subject demographics and clinical outcome were collected from electronic medical records.ResultsPNI was identified in 23% (3/13) of tumors in the original reports, 13% (4/31) of the authors' re-review of the slides, and 29% (9/31) of cases reacted with S100. PNI and larger-diameter nerve involvement were significantly associated with death at 5-year follow-up.ConclusionsImmunohistochemical enhancement improves the accuracy and speed of PNI determination. PNI is a significant factor in the survival outcome of cases of MEC.



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