Evaluation of the anti-inflammatory action of curcumin analog (DM1): effect on iNOS and COX-2 gene expression and autophagy pathways

Publication date: Available online 16 March 2016
Source:Bioorganic & Medicinal Chemistry
Author(s): Niraldo Paulino, Amarilis Scremin Paulino, Susana N. Diniz, Sergio de Mendonça, Ivair D. Gonçalves, Fernanda Faião Flores, Reginaldo Pereira Santos, Carina Rodrigues, Paulo Celso Pardi, José Agustin Quincoces Suarez
This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.

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