The Incidence and Clinical Features of Dual Thyroid Ectopia in Congenital Hypothyroidism.

The Incidence and Clinical Features of Dual Thyroid Ectopia in Congenital Hypothyroidism.

J Clin Endocrinol Metab. 2016 Mar 18;:jc20153080

Authors: Tucker D, Woods G, Langham S, Biassoni L, Krywawych S, Hindmarsh P, Peters C

Abstract
CONTEXT: Congenital Hypothyroidism (CH) may arise from dual foci thyroid ectopia.
OBJECTIVE: To ascertain the incidence of dual ectopia in CH and compare the phenotype to single ectopia or thyroid agenesis.
DESIGN AND SETTING: Single centre, retrospective study of babies referred through UK Newborn Bloodspot Screening between 2006-2012.
PATIENTS: 837,377 babies were screened for CH with 730 referred for diagnostic confirmation (134 thyroid ectopia; 73 thyroid agenesis).
INTERVENTION: Thyroid isotope scans classified as single or dual ectopia. Biochemical, clinical and sociodemographic data were collected.
MAIN OUTCOME MEASURES: The incidence of thyroid dual ectopia and comparison of clinical parameters with single ectopia and agenesis.
RESULTS: Thyroid ectopia occurs with an incidence of 16 /100,000 births. 21/134 (15.7%) babies with thyroid ectopia had dual foci; an incidence of 2.5 /100,000 births. Dual ectopia infants had lower mean bloodspot TSH compared to single ectopia and agenesis groups (P<0.001). On venous sampling the Ectopia group differences were absent but the difference with the agenesis group remained (TSH P<0.001; FT4: P<0.001). There were no between-group differences for gestation, ethnicity, maternal age or levthyroxine requirements at 12 months.
CONCLUSIONS: Thyroid dual ectopia has an incidence of 2.5 /100,000 births. Early functional activity in the ectopia groups with detectable serum FT4 concentrations, is lost at 12 months when thyroxine requirements are the same as the agenesis group.

PMID: 26990941 [PubMed - as supplied by publisher]

from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1ZcyGMf
via IFTTT