Abstract
Aim
We analyzed the clinicopathologic features and immunohistochemical characteristics of 9 cases of salivary duct carcinoma (SDC) with rhabdoid features (SDCRF), representing a new, extremely rare type of salivary gland malignancy.
Methods and results
We analyzed 2511 cases of salivary gland tumors, clinicopathologically and immunohistochemically. The incidence of SDCRF was 0.4%. Eight patients were male. Age ranged from 36–85 years (mean, 61 years). SDC arose from the parotid glands and submandibular gland in 6 and 3 cases, respectively. Seven cases appeared as a carcinoma component of carcinoma ex pleomorphic adenoma (CXPA) cases. Six patients died from disease. Histologically, diffuse proliferation of non-coherent large ovoid or polygonal carcinoma cells with eosinophilic cytoplasm and eccentric nuclei were observed in all cases; such cytological characteristics were defined as "rhabdoid features." Immunohistochemically, all cases were positive for cytokeratin, gross cystic disease fluid protein-15, androgen receptor, and SMARCB1; 7 cases were positive for Her-2, whereas two cases were positive for epidermal growth factor receptor. However, all cases were negative for vimentin and myoepithelial markers. Eight cases showed no or aberrant expression of E-cadherin and β-catenin. The results suggest SDCRF is an extremely rare subtype of SDC, not sarcomatoid variant SDC. SDCRF is histologically unique and is positive for SDC markers but negative for vimentin, unlike rhabdoid type carcinomas arising from other organs.
Conclusions
The morphogenesis of SDCRF is related to no or aberrant expression of cell–cell adhesion molecules. Therefore, SDCRF could be a salivary counterpart to pleomorphic lobular breast carcinoma.
This article is protected by copyright. All rights reserved.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Vp9EKJ
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου