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Δευτέρα 16 Μαΐου 2016

N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases

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Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC02520J, Communication
Andres Gonzalez, Grishma Vadlamani, Brian L Mark, Stephen G. Withers
Mono-, di- and trisaccharide derivatives of 1,2-unsaturated N-acetyl-D-glucal have been synthesized and shown to function as tight-binding inhibitors/slow substrates of representative hexosaminidases. Turnover is slow and not observed in the...
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