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Τετάρτη 1 Ιουνίου 2016

Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC03501A, Communication
Annabel C Murphy, Hui Hong, Steven Vance, R. William Broadhurst, Peter Francis Leadlay
An in vitro model system based on a ketosynthase domain of the erythromycin polyketide synthase was used to probe the apparent substrate tolerance of ketosynthase domains of the mycolactone polyketide...
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