Abstract
Background
Influenza A and Respiratory Syncytial Virus (RSV) has been recognized as a major cause of acute respiratory tract infection. H1N1 is one of the subtypes of influenza A, pandemic worldwide in July2009, causing 18,449 deaths globally.
Objectives
To investigate the prevalence and clinical manifestation of the influenza A, H1N1pdm09 and RSV.
Method
Throat/nasal swab collected from the patients of all age group either outpatients/inpatients having respiratory illness from 2 to 5 days. The clinical data were recorded in a predesigned questionnaire. RNA was extracted and analyzed by real time PCR at a tertiary care center, 2009–2014.
Results
Total 4352 samples tested for influenza A and H1N1. Out of 4352, 32.2% (median positivity 21%; range 16-41% during six years) were positive for influenza A and 19% were H1N1 (median positivity 16.7%; range 8.7-23% during six years). Total 1653 samples were analyzed for RSV from 2011-2014, 12% were RSV positive (median positivity11.35%; range 10-16.3% during four years). Pharyngitis, dyspnea were frequent symptoms in influenza A and H1N1 (p < 0.005) whereas bronchiolitis and pneumonia were commonly present in RSV (p < 0.005). The positivity of influenza A and H1N1 was higher in age-group 21-30, whereas RSV in infant and children.
Conclusion
H1N1and RSV were co-circulated and have common clinical symptoms particularly in lower age group. Therefore, laboratory confirmation is necessary for further disease prognosis. Age was an important risk factor that affects the positivity of influenza A, H1N1 and RSV. Different clinical manifestation of H1N1 and RSV will be helpful for early and accurate diagnosis. This article is protected by copyright. All rights reserved
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