Analytical data in support of the liver and peripheral blood concentration (L/P) ratio as a marker of postmortem redistribution

2016-06-22T04-06-49Z
Source: European Journal of Forensic Sciences
Iain M McIntyre.
Postmortem redistribution (PMR) refers to the changes that can occur in drug concentrations after death. Consequently, postmortem blood concentrations may not always reflect the antemortem drug levels. A recent literature review has postulated a model describing drugs with a liver (L) to peripheral blood (P) concentration ratio less than 5 L/kg as being prone to little or no PMR, while drugs with an L/P ratio greater than 20-30 L/kg exhibit propensity for substantial PMR. Antidepressants including tricyclic antidepressants and some selective serotonin re-uptake inhibitors, for example, were obviously distinguished from drugs confirmed to be free from, or demonstrate little PMR. This current paper presents analytical L/P data from 867 postmortem cases yielding a ranking of 44 different drugs propensity for (and degree of) PMR.


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