Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance

The treatment of Stenotrophomonas maltophilia infection with beta-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded beta-lactamases. Here, we show that these beta-lactamase-packed OMVs are capable of establishing extracellular beta-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating species Pseudomonas aeruginosa and Burkholderia cenocepacia.

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