Abstract
Background
Urothelial carcinoma (UC) is a globally common cancer. miR-21 appears to be important in the tumourigenesis of almost all types of human cancer. However, its precise localization and significance in UC have yet to be clarified. We examined miR-21 expression in UC and revealed its clinicopathological importance.
Methods
Tissue arrays of 232 UCs were examined for miR-21 using in situ hybridization. One- hundred forty-eight TUR specimens and 84 surgically resected specimens were used. After miR-21 positivity was evaluated separately in tumour cells and tumour stroma, it was compared with clinicopathological factors and overall survival.
Results
miR-21 was strongly expressed in tumour cells in 9% of cases and in cancer stroma in 6% of cases. Stromal miR-21 was less than cancerous miR-21. Both miR-21 were correlated with each other and related to tumour stage, locus, and histological grade. In addition, strong positivity of miR-21 in cancer and stroma was significantly related to poorer prognosis among surgically resected cases. In a Cox proportional hazard model, cancerous miR-21 was the only independent prognostic factor except for tumour stage.
Conclusion
miR-21 in both cancer and stromal cells is closely related to tumour progression in UC. miR-21 may be a prognostic marker for cancer progression.
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