Toluene down-regulates filaggrin expression via the ERK and STAT3 – dependent pathways

Publication date: Available online 4 August 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Hana Lee, Jung Jin Shin, Hyun Cheol Bae, Woo-In Ryu, Sang Wook Son

Teaser

We investigated the effect of toluene on the skin barrier. The present study suggests that toluene may contribute to epidermal barrier dysfunction through down-regulation of filaggrin expression by the STAT3 and ERK1/2 signaling pathway.


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