FORMULATION AND CHARACTERIZATION OF THEOPHYLLINE HYDRO GELS USING FREEZE THAW AND CHEMICAL POLYMERIZATION METHODS

2016-09-12T01-57-19Z
Source: Indo American Journal of Pharmaceutical Research
Nagamani Bolla*, V. Ramalingeswa Rao, GSN Koteswara Rao T. Amruta Rai, P. Uma Devi.
The development of topical formulations has been a challenge to formulation scientists because solubility, permeability, half life of the drug etc governs the absorption of the drug. Hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids and are held together by chemical or physical bonds. Theophylline is used as a bronchodilator but in lower concentrations it can be used as an analgesic. Theophylline hydrogels were formulated using two different techniques, Chemical Polymerization (crosslinking agent - borax in different concentrations) and Freeze thaw technique. Sodium hyaluronate and polyvinyl alcohol as polymers with gelatin base and PEG 600 as a permeation enhancer. This was the first report on Theophylline anti inflammatory hydrogels formulated using sodium hyaluronate using different methods, Sodium hyaluronate, one of the polymers which is a safer polymer present in the connective tissue of human body and can be used without causing any toxic effect to the skin.


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