FORMULATION AND EVALUATION OF HERBAL EMULGEL OF LANTANA CAMARA LEAVES EXTRACT FOR WOUND HEALING ACTIVITY IN DIABETIC RATS

2016-09-12T01-57-19Z
Source: Indo American Journal of Pharmaceutical Research
Sk. Shaheda Sultana*, G.Swapna, G. Sai Sri Lakshmi, S. Swathi, G. Nirmala Jyothi, A. Seetha Devi.
The main aim of this work was to formulate the leaf extract of Lantana camara in to an emulgel and investigate their excision wound healing activity in Diabetic rats. Ethanolic extract of dried leaves of Lantana camara were subjected to preliminary phytochemical evaluation. Emulgel formulations were prepared using different types of gelling agents: Carbopol 934, Na CMC, HPMC, HPMC K15M, and HEC. The influence of the type of the gelling agent on the drug release from the prepared emulgel was investigated. The prepared emulgel were evaluated for their physical appearance, pH, Viscosity, Spreadability, in-vitro drug release, pharmacological activity and stability. From the results it was found that the formulation EGF2 with 1%w/w Sodium CMC shows better drug release (92.8% at 8 h) and higher pharmacological activity compared to other formulations. Herbal emulgel of ethanolic extract of Lantana camara shows significant improvement in excision wound contraction and hence this is a promising candidate for wound healing in diabetic rats.


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